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易凡
作者:  来源:  发布时间:2010-06-04 01:22:06  浏览次数:26125

 


易凡,教授、 博士生导师; 国家杰出青年基金、教育部新世纪优秀人才,山东省杰出青年基金及山东省“五四”青年奖章获得者。一直致力于肾脏病的发病机制研究,留学美国9年,获得博士学位并完成博士后训练后于2008 8月全职回国,在山东大学医学院组建了以探讨肾脏病发病机制为核心,以临床问题为先导,以药物靶点发现为目标的独立的肾脏病研究团队。在研究方向上,以糖尿病肾病为中心,以探讨肾脏局部炎性反应的调控机制为重点,为寻找新的药物靶点和肾脏病的防治提供重要的理论依据和实验基础。在该领域总共发表SCI论文56篇,它引次数1177H-index23

教育经历

2006.1–2008.7 Hypertension and Kidney Research Center,

Virginia Commonwealth University Health CenterUSA博士后

研究方向:肾脏病的发病机制研究

2002.8-2006.1 Department of Physiology and Department of Pharmacology,

Medical College of WisconsinUSA,美国威斯康星医学院 博士,

研究方向:肾脏病的病理生理学

1999.8-2002.7 University of Wisconsin-Madison,School of Pharmacy,USA

美国威斯康星大学-麦迪逊分校, 药学院,硕士,

1996.8-1999.7 中国科学院化学研究所,硕士

1992.9-1996.7 山东大学化学院,学士

工作经历

2014.3-现在  山东大学肾脏病研究所      副所长

2012.5-现在  山东大学齐鲁医学部 教学科研处处长

山东大学医学院药理学系    主任

                    山东大学医学院学术委员会  委员

2008.8-现在  山东大学医学院药理学系 教授,博士生导师

            肾脏与免疫方向 PI

主持或参加科研项目及人才计划项目情况

1.国家杰出青年基金  81525005  肾脏病的发病机制 2016/1-2020/12 400

2.  国家自然科学基金面上项目 81470958  Progranulin在糖尿病肾病足细胞损伤中的保护作用及分子机制, 2015/1-2018/1273万,在研, 主持

3.  国家自然科学基金面上项目 81170772  NOD样受体介导的免疫调控在糖尿病肾病中的作用机制及干预策略, 2012/1-2015/1255万,在研, 主持

4. 国家自然科学基金面上项目 81070572  TNFAIP8家族在糖尿病肾病中的作用及机制研究, 2011/1-2013/1238万,已结题,主持

5. 973国家重点基础研究发展计划 2012CB517700 慢性肾脏病进展的机制研究, 2012/1-2016/692万,在研,学术骨干

6. 教育部新世纪优秀人才支持计划 NCET-11-0311 糖尿病肾病的发病机制,2012/1- 2014/1250万,在研,主持

7. 山东省自然科学杰出青年基金 JQ201121 糖尿病肾病的发病机制及新型靶点药物的药理学研究, 2012/1-2014/12 50万,已结题,主持

主要学术任职

中国生理学会肾脏专业委员会              委员

中国药理学会                            理事

中国细胞生物学会医学细胞生物学分会      常务理事

山东省药理学会                          副理事长

The Anatomical Record (USA SCI收录)    编委

Journal of Geriatric Cardiology  (SCI收录)   编委

Kidney Diseases                          编委 

中国细胞生物学报、解剖学报             编委

学术荣誉

国家杰出青年基金 2016 (已公示2015-08-04-2015-08-18

第二届中国“SCOPUS寻找青年科学之星新人奖, 2010

14山东青年五四奖章2010 (全省20/年获此荣誉)

教育部新世纪优秀人才支持计划入选者, 2011

山东省自然科学杰出青年基金获得者, 2011 (全省20/年获此荣誉)

中国药理学会优秀青年药理学工作者奖, 2012

山东省优秀硕士论文指导教师, 2013

发表论文:

1.   Zhou M, Tang W, Fu Y, Xu XY, Wang ZY,Lu Y, Liu F, Yang XY, Zhang Y, Liu J, Geng Y, Zhang X, Wan Q, Li NJ, Yi F* (通讯作者). Progranulin protects against renal ischemia/reperfusion injury in mice. Kidney International.  2015; 87: 918-929. (IF:8.52)

This article was highlighted in In this issue and was honored by an editorial commentary(编辑特邀评述):

Tadagavadi RK, Reeves WB. NODding off in acute kidney injury with progranulin? Kidney International. 2015; 87(5):873-875

2.  Shang J, Wang Q, Wang XJ, Duan YQ, Zhang Y, Wang ZY, Wei XB, Wang R*, Yi F* (通讯作者) Identification of NOD2 as a novel target of RNA-binding protein HuR: Evidence from NOX4-mediated HuR signaling in diabetic nephropathy. Free Radic Biol Med. 79:217-227, 2015 (IF:5.71)

3.   Wang XJ, Yi F* (通讯作者). Implication of Pattern-recognition Receptors in Cardiovascular Diseases. Antioxid Redox Sign  2014 Nov 11. [Epub ahead of print]IF:7.71

4.  Wang ZYQin W, Yi F* (通讯作者). Targeting Histone DeacetylasesPerspectives for Epigenetic-based Therapy in Cardio-cerebrovascular Disease. J Geriatr Cardiol 2015; 12(2):153-64. (特约评述)

5.  Wang XJ, Liu J, Zhen JH, Zhang C, Wan C, Liu GY, Wei XB, Zhang Y, Bao CC, Song ZY, Zhang XM, Li N, Yi F* (corresponding author). HDAC4 Selectively Contributes to Podocyte Injury in Diabetic Nephropathy Kidney International. 86(4):712-25, 2014, (IF:8.52)

This article was highlighted in “In this issue” and was honored by an editorial commentary(编辑特邀评述):

Wei Q, Dong Z.HDAC4 blocks autophagy to trigger podocyte injury: non-epigenetic action in diabetic nephropathy. Kidney International. 2014, 86(4):666-8, 2014

6.  Yang F, Wang ZY, Wei XB, Han HR, Meng XF, Zhang Y, Shi WC, Li FL, Xin T, Pang Q*, Yi F* (通讯作者). NLRP3 Deficiency Ameliorates Neurovascular Damage in Experimental Is chemic Stroke. J Cereb Blood Flow Metab 34(4):660-7,2014 (IF: 5.66)

7.  Han H, Yi F* (通讯作者). New insights into TRP channels: Interaction with pattern recognition receptors. Channels (Austin). 8(1):13-9, 2014 (invited review) (IF: 2.66)

8.  Du P, Fan B, Han H, Zhen J, Shang J, Wang X, Li X, Shi W, Tang W, Bao C, Wang Z, Zhang Y, Zhang B, Wei X, Yi F* (通讯作者). NOD2 promotes renal injury by exacerbating inflammation and podocyte insulin resistance in diabetic nephropathy. Kidney International. 84(2):265-76, 2013 (IF:8.52)

This article was highlighted in “In this issue” and was honored by an editorial commentary(编辑特邀评述):

Anders HJ,LechM. NOD-like and Toll-like receptors or inflammasomes contribute to kidney disease in a canonical and a non-canonical manner. Kidney Int. 84(2):225-8, 2013

9.   Han HR, Wang YP, Li X, Wang PA, Wei XB, Liang W, Di GH, Yu X, Bao CC, Zhang Y, Wang Z, Yi F* (通讯作者). Novel Role of NOD2 inMediating Ca2+ Signaling: Evidence from NOD2-regulated Podocyte TRPC6 Channels in Hyperhomocysteinemia. Hypertension 62(3):506-511, 2013 (IF:7.63).

This article was selected as a cover paper(封面文章)

10.   He M, Zhang B, Wei X, Wang Z, Fan B, Du P, Zhang Y, Jian W, Chen L, Wang L, Fang H, Li X, Wang PA, Yi F* (通讯作者). HDAC4/5-HMGB1 signalling mediated by NADPH oxidase activity contributes to cerebral ischemia/reperfusion injury. J Cell Mol Med. 17(4):531-542,2013 (IF:4.78)

11.  Wang ZY, Wei XB, Liu K, Zhang XM, Zhang HY, He YT, Zhu TF, LI FL, Shi WC, Zhang Y, Yi F* (通讯作者). NOX2 Deficiency Ameliorates Cerebral Injury by Reduction of Complexin II-mediated Glutamate Excitotoxicity in Experimental Stroke. Free Radic Biol Med. 65:942-51,2013  (IF:5.71)

12.  Li X, Li FL, Chu YL, Wang XJ, Zhang HY, HU YY, Zhang Y, Wang ZY, Jian WC, Zhang XM, Yi F* (通讯作者). NOD2 Deficiency Protects against Cardiac Remodeling after Myocardial Infarction in Mice. Cell Physiol Biochem 32:1857-1866, 2013 (IF: 3.55)

13.  Zhang Y, Wei X, Liu L, Liu S, Wang Z, Zhang B, Fan B, Yang F, Huang S, Jiang F, Chen YH, Yi F* (通讯作者), TIPE2, a Novel Regulator of Immunity, Protects against Experimental Stroke. J Biol Chem. 287(39):32546-55, 2012 IF:5.11

14.  Wang XJ, Wei XB, Pang Q*, Yi F* (通讯作者), Histone deacetylases and their inhibitors: molecular mechanisms and therapeutic implications in diabetes mellitus, Acta Pharmaceutica Sinica B 2(4):387-395, 2012

15.  Zhang S, Zhang Y, Wei X, Zhen J, Wang Z, Li M, Miao W, Ding H, Du P, Zhang W, He M, Yi F* (通讯作者). Expression and regulation of a novel identified TNFAIP8 family is associated with diabetic nephropathy. Biochim Biophys Acta-Molecular Basis of Disease. 802(11):1078-862010 IF:5.2

16.  Yi F* (通讯作者), Jin S, Li PL. Lipid raft-redox signaling platforms in plasma membrane. Methods Mol Biol. 2009; 580:93-107.

17.  Fu Y, Zhang Y, Wang Z, Wang L, Wei X, Zhang B, Wen Z, Fang H, Pang Q, Yi F* (通讯作者). Regulation of NADPH Oxidase Activity Is Associated with miRNA-25-Mediated NOX4 Expression in Experimental Diabetic Nephropathy. Am J Nephrol. 11;32(6):581-5892010 IF:2.68

18. Wang ZY, Wei XB,  Zhang Y, Ma XL, Li, BQ, Zhang SX, Du, PC, Zhang XM, Yi F* (通讯作者). NADPH oxidase-derived ROS contributes to upregulation of TRPC6 expression in puromycin aminonucleoside-induced podocyte injury. Cell Physiol Biochem 24:619-26, 2009IF:3.55

19.  Yi F, Xia M, Zhang C, Tang L, Li N, Li PL. Contribution of Guanine Nucleotide Exchange Factor-Vav2 to Hyperhomocysteinemic Glomerulosclerosis in Rats. Hypertension, 5390-962009 IF:7.63

20.  Yi F, Zhang AY, Li N, Muh RW. Fillet M, Renert AF, Li PL. Inhibition of ceramide–Redox signaling pathway blocks glomerular injury in hyperhomocysteinemic Rats, Kidney International. 70:88-96, 2006 IF:8.52

21. Yi F, Zhang AY, Janscha JL, Li PL, Zou AP. Homocysteine activates NADH/NADPH oxidase through ceramide-stimulated Rac GTPase activity in rat mesangial cells. Kidney International  66:1977-87, 2004. IF:8.52

22.  Zhang AY*, Yi F* (co-first author), Jin S, Xia M, Chen QZ, Gulbins E, Li PL. Lipid raft redox signaling platforms in endothelial dysfunction in coronary arteries: role of acid sphingomyelinase, Antioxid Redox Sign 9:817-828, 2007  IF:7.71

23.   Yi F, Jin S, Zhang F, Xia M, Bao JX, Hu J, Poklis J, Li PL. Formation of Lipid Raft Redox Signaling Platforms in Glomerular Endothelial Cells: An Early Event of Homocysteine-Induced Glomerular Injury  J Cell Mol Med. 13:3303-142009. IF:4.78

24.   Yi F, Li PL. Mechanism of homocysteine-induced glomerular injury and sclerosis Am J Nephrol, 28: 254-264, 2008 (IF:2.68)

25.   Yi F, Zhang AY, Li N, Zhang F, Mia M, and Li PL. Role of cyclic ADP-ribose-Ca2+ signaling in mediating renin production and release in As4.1 cells. Cell Physiol Biochem 19:293-302, 2007 IF:3.48

26.   Yi F, Santos E, Xia M, Chen QZ, Li PL and Li N. Podocyte injury and glomerulosclerosis in Hyperhomocysteinemic Rats.  Am J Nephrol 27:262-268, 2007  IF:2.68

27.  Yi F, Chen QZ, Jin S, Li PL. Mechanism of Homocysteine-induced Rac1/NADPH Oxidase Activation in Mesangial Cells: Role of Guanine Exchange Factor Vav2. Cell Physiol Biochem 20:909-918,2007 IF:3.55

28.  Wang S, Luo Y, Feng A, Li T, Yang X, Nofech-Mozes R, Yu M, Wang C, Li Z, Yi F, Liu C, Lu WY. Ethanol induced impairment of glucose metabolism involves alterations of GABAergic signaling in pancreatic β-cells. Toxicology4;326:44-52, 2014 IF:3.75

29.  Hu J, Zhu Q, Xia M, Guo TL, Wang Z, Li PL, Han WQ, Yi F, Li N.Transplantation of mesenchymal stem cells into the renal medulla attenuated salt-sensitive hypertension in Dahl S rat. J Mol Med (Berl). 2014 Aug 19. [Epub ahead of print] IF:4.52

30.  Zhang Y, Inks ES, Zhu M, Chou CJ, Fang H, Li M, Shen Y, Yi F, Xu W. Discovery of a Pair of Diastereomers as Potent HDACs Inhibitors: Determination of Absolute Configuration, Biological Activity Comparison and Computational Study. RSC Adv. 3(43). 2013doi: 10.1039/C3RA43249A.

31.  Xiong J, Xia M, Yi F, Abais JM, Li N, Boini KM, Li PL. Regulation of renin release via cyclic ADP-ribose-mediated signaling: evidence from mice lacking CD38 gene. Cell Physiol Biochem. 31(1):44-55, 2013 (IF:3.48)

32.  Liu H, Liu X, Wei X, Chen L, Xiang Y, Yi F, Zhang X. Losartan, an angiotensin II type 1 receptor blocker, ameliorates cerebral ischemia-reperfusion injury via PI3K/Akt-mediated eNOS phosphorylation. Brain Res Bull. 89(1-2):65-70, 2012 (IF:2.88)

33.  Guan P, Sun F, Hou X, Wang F, Yi F, Xu W, Fang H. Design, synthesis and preliminary bioactivity studies of 1,3,4-thiadiazole hydroxamic acid derivatives as novel histone deacetylase inhibitors. Bioorg Med Chem. 20(12):3865-72,2012 (IF:2.903)

34.  Wang Z, Tang L, Zhu Q, Yi F, Zhang F, Li PL, Li N.Hypoxia-inducible factor-1α contributes to the profibrotic action of angiotensin II in renal medullary interstitial cells. Kidney Int. 79(3):300-10, 2010 IF:7.91

35.  Zhang C, Yi F, Xia M, Boini KM, Zhu Q, Laperle LA, Abais JM, Brimson CA, Li PL. NMDA Receptor-Mediated Activation of NADPH Oxidase and Glomerulosclerosis in Hyperhomocysteinemic Rats. Antioxid Redox Signal. 13:975-86,2010 IF:7.19

36.   Galm U, Wendt-Pienkowski E, Wang L, George NP, Oh TJ, Yi F, Tao M, Coughlin JM, Shen B. The biosynthetic gene cluster of zorbamycin, a member of the bleomycin family of antitumor antibiotics, from Streptomyces flavoviridis ATCC 21892. Mol Biosyst. 5:77-90, 2009 IF:4.2

37.  Li N, Chen L, Yi F, Xia M, Li PL.Salt-sensitive hypertension induced by decoy of transcription factor hypoxia-inducible factor-1alpha in the renal medulla. Circulation Research.  102:1101-8, 2008 (IF:11.8)

38.  Jin S, Yi F, Zhang F, Poklis JL, Li PL. Lysosomal Targeting and Trafficking of Acid Sphingomyelinase to Lipid Raft Platforms in Coronary Endothelial Cells. Arterioscler Thromb Vasc Biol. 282056-20622008  (IF:6.37)

39.  Zhang F, Jin S, Yi F, Li PL. TRP-ML1 Functions as a Lysosomal NAADP-Sensitive Ca(2+) Release Channel in Coronary Arterial Myocytes. J Cell Mol Med. 13(9B):3174-85, 2009 (IF:4.77)

40. Jia SJ, Jin S, Zhang F, Yi F, Dewey WL, Li PL. Formation and Function of Ceramide-Enriched Membrane Platforms with CD38 during M1-Receptor Stimulation in Bovine Coronary Arterial Myocytes. Am J Physiol Heart Circ Physiol. 195:1743-1752,2008 IF:3.6

41. Zhang F, Jin S, Yi F, Xia M, Dewey WL, Li PL.Local production of O2- by NAD(P)H oxidase in the sarcoplasmic reticulum of coronary arterial myocytes: cADPR-mediated Ca2+ regulation. Cell Signal. 20:637-44 2008 (IF:4.3)

42. Jin S, Zhang Y, Yi F, Li PL. Critical role of lipid raft redox signaling platforms in endostatin-induced coronary endothelial dysfunction. Arterioscler Thromb Vasc Biol. 28:485-90, 2008 IF:6.37

43.  Li N, Yi F, Santos E, Donley D, Li PL. Role pf medullary heme oxygenase in the regulation of pressure natriuresis and arterial blood pressure. Hypertension 49:148-54, 2007. IF6.87

This article was honored by an editorial commentary (编辑特邀评述):

Control of renal Na+ excretion by heme oxygenase Hypertension 49: 23-24, 2007)

44.  Li N, Yi F, Sundy CM, Chen L, Hilliker ML, Donley DK, Muldoon DB, Li PL. Contribution of prolyl hydroxylase to the control of renal function and arterial blood pressure. Am J Physiol Renal Physiol. 292:F207-216, 2007 IF:3.9

45.  Zhang G, Zhang F, Muh RW, Yi F, Chalupsky K, Cai H, Li PL. Autocrine/paracrine pattern of superoxide production through NAD(P)H oxidase in coronary arterial. Am J Physiol Heart Circ Physio 292: H483-495, 2007 IF:3.6

46.  Jin S, Yi F, Li PL. Contribution of lysosome-like vesicles in the formation of lipid raft redox signaling platform. Antioxid Redox Sign  9:1417-1426, 2007. IF:7.19

47.  Li PL, Zhang AY, Yi F. Lipid raft redox signaling platforms and endothelial dysfunction induced by activation of death factors. Antioxid Redox Sign 9:1457-1470, 2007. IF:7.19

48.  Li PL, Yi F, Li N. Hyperhomocysteinemia-Associations with renal transsulfuration and redox signaling in rats. Clin Chem Lab Med 45:1688-93, 2007

49.  Zhang AY, Yi F, Zhang G, Gulbins E, Li PL. Lipid rafts clusering and redox signaling platform formation in coronary arterial endothelial cells. Hypertension 47:74-80, 2006. This article was honored by an editorial commentary(编辑特邀评述):

Lipid rafts take center stage in endothelial cell redox signaling by death receptors” Hypertension 47:16-18, 2006. IF:6.87

50.   Yi XU, Li VX, Zhang F, Yi F, Matson DR, Siebenaler JF, Jiang MT, Zou AP, Li PL. Biochemical and functional characteristics of an NAD(P)H oxidase in the sarcoplasmic reticulum of coronary vascular smooth muscle. Am J Physiol-Heart Circ Physiol. 290: H1136-1144, 2006. IF:3.6

51.  Zhang G, Teggatz EG, Zhang AY, Yi F, Koeberl MJ, Chen L, Li PL. Cyclic ADP-ribose-mediated cyclic Ca2+ signaling in mediating endothelial nitric oxide production in bovine coronary arteries. Am J Physiol-Heart Circ Physiol.290: H1172-1181, 2006. IF:3.6

52.   Shen B, Chen M, Cheng Y, Du L, Edwards DJ, George NP, Huang Y, Oh T, Sanchez C, Tang G, Wendt-Pienkowski E, Yi F. Prerequisites for combinatorial biosynthesis: evolution of hybrid NRPS/PKS gene clusters. Ernst Schering Res Found Workshop. 51:107-126, 2005.

53.  Teggatz EG, Zhang G, Zhang AY, Yi F, Li PL. cyclic ADP-Ribose-mediated Ca2+ signaling and Ca2+-induced Ca2+ release in renal arterial smooth muscle cells. Microvasc Res. 70:65-75, 2005. IF:3.0

54.  Zhang AY, Yi F, Teggatz E, Zou AP, Li PL. Reactive oxygen species enhances cyclic ADP-Ribose production and intracellular calcium mobilization in small bovine coronary arterial smooth muscle. Microvasc Res. 67:159-167, 2004. IF:3.0

 

联系方式:

fanyi@sdu.edu.cn

Tel:0531-88382616 

 

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